The statement describes a research project focused on using and refining metabolomics methodologies for complex congenital heart disease, specifically perioperative investigation of Fontan disease. The team is collaborating with clinicians and intensivists to plan sample collections and is exploring the use of commercially available blood microsampling devices to reduce patient burden. The goal is to unlock metabolic pathway information to facilitate earlier medical intervention. The work stands out due to the multidisciplinary team of analytical chemists, chemometricians, and clinicians, as well as the focus on improving patient experience, enhancing accessibility to healthcare, enabling earlier detection and intervention, and improving monitoring and management of heart conditions.